Diosmin

power of Diosmin 520-27-4,99%,White crystalline powder,vitamin P-like effects PRODUCT NAME Diosmin CAS NO. 520-27-4 CHEMICAL NAME 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl] oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran- 4-one EXTRACT ORIGIN Synthetic APPEARANCE White crystalline powder SPECIFICATION 99% MOLECULAR FORMULAF C28H32O15 CHEMICAL STURUCTURE FUNCTION With vitamin P-like effects, and can reduce the fragility and abnormal vascular permeability, but also for the prevention and treatment of hypertension and arteriosclerosis in adjuvant therapy for the treatment of capillary fragility more effective than rutin, hesperidin stronger, and has low toxicity features. Treatment of hemorrhoids, chronic venous insufficiency, etc. Diosmin Test Specifications Ph.Eur. 6.0 Items tested Specifications Results Characters A greyish-yellow or light yellow hygroscopic powder. A greyish-yellow hygroscopic powder. Identification Spectrogram obtained by the substance to be examined conforms to that obtained by the reference substance. Spectrogram obtained by the substance to be examined conforms to that obtained by the reference substance. The principle peak in the chromatogram obtained with the test solution is similar in etention time and size to the principal peak in the chromatogram obtained with reference solution (a). The principle peak in the hromatogram obtained with the test solution is imilar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a). Solubility Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol it dissolves in dilute solutions of alkali hydroxides. Complies Iodine ≤ 0.1% Complies Substances Impurity A(Acetoisovanillone) ≤1% Not detected Impurity B(Hesperidin): ≤5% 2.8% Impurity C(Isorhoifolin): ≤3% 1.0% Impurity E(Linarin): ≤3% 1.1% Impurity F(Diosmitin): ≤3% 0.9% Any other impurity: ≤1% 0.3% Total of other impurities and impurity A ≤1% 0.3% Total impurie ≤10% 6.4% Heavy metals ≤20ppm Complies Water ≤6.0% 3.42% Sulphated Ash ≤0.2% 0.09% Pyridine ≤200ppm 103ppm Assay (HPLC) 90.0%~102.0% 93.9% Conclusion The batch of Diosmin meets the specification required by Ph.Eur.6.0 Certificate of Analysis Items Standards Results Appearance Greyish-yellow to ligh yellow hygroscopic powder Complies Identification A. Infrared absorption spectrophotometry B. Examine the chromatograms obtained in the Assay Comparaison:diosmin CRS The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution.(a) Complies Complies Solubility Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol, it dissolves in dilute solution of alkali hydroxides Complies Iodine content ≤0.1% 0.00% ImpurityA (acetoisovanillone) ≤1.0% 0.18% Impurity B (Hesperidin) ≤5.0% 2.72% Impurity C(Isorhoifin) ≤3.0% 2.31% Impurity E (linarin) ≤3.0% 1.32% Impurity F(Diosmetin) ≤3.0% 0.61% Others impurities ≤1.0% 0.58% Total of other impurities and impurity A ≤1.0% 0.62% Total ≤10.0% 7.23% Heavy metals ≤20ppm Complies Water content ≤6.0% 3.19% Sulphated ash ≤0.2% 0.14% Assay (HPLC) (Anhydrous substance) 90.0 102.0% 91.63% Residual solvents -Methanol -Ethanol -Pyridine ≤3000ppm ≤0.5% ≤200ppm 150ppm 250ppm 10ppm Total plate count ≤1000cfu/g Complies Yeasts&Molds ≤100cfu/g Complies S. aureus Negative in 1g Negative Salmonella Negative in 1g Negative E.coli Negative in 1g Negative Staphylococcus Negative in 1g Negative Aflatoxins Negative in 1 g Complies Storage Store in dry place with seal and keep away from moisture and direct sun light