Tetrahydrofuran

Key Parameters and Applications of Tetrahydrofuran (THF)

‌I. Basic Physical and Chemical Parameters‌

1. ‌Molecular Properties‌

   • Chemical formula: C₄H₈O, Molecular weight: 72.11, CAS number: 109-99-912
   • Appearance: Colorless transparent liquid with an ether-like odor, partially miscible with water15

2. ‌Physical Properties‌

   • Density: 0.89-0.90 g/cm³, Boiling point: 66°C, Melting point: -108.4°C25
   • Flash point: -21°C (flammable), Vapor pressure: 152.4 mmHg (25°C)25
   • Refractive index: 1.417, Polarity: Medium (LogP=0.33)28

3. ‌Stability and Storage‌

   • Requires storage away from light and sealed (warehouse temperature ≤29°C), often with BHT antioxidant added to prevent peroxide formation28
   • Prohibited: Keep away from oxidizers, strong acids/bases; storage area must be explosion-proof and ventilated23

‌II. Core Application Areas‌

1. ‌Organic Synthesis‌

   • Universal solvent: Used in Grignard reactions, metal-catalyzed reactions, esterification reactions, etc.78
   • Polymerization medium: Synthesis of polyurethane (PTMEG), polyacrylate, and other polymer materials47

2. ‌Electronics Industry‌

   • Semiconductor manufacturing: Photoresist dilution and cleaning, substrate cleaning for LCD panels46
   • Electronic-grade THF: Purity ≥99.9%, metal ions ≤1ppb, used for precision component cleaning6

3. ‌Chemical and Materials Industry‌

   • Resin solvent: PVC coatings, magnetic tape coatings, cellophane coatings8
   • Natural gas odorant, mobile phase for gel permeation chromatography8

4. ‌Pharmaceuticals and Testing‌

   • Intermediate for antibacterial drug synthesis (e.g., furaltadone)1
   • HPLC mobile phase for analysis of alkaline compounds4