Triethylamine

Key Parameters and Applications of Triethylamine () are as follows:

I. Basic Physicochemical Parameters

1. Molecular Properties

   • Molecular formula: C₆H₁₅N, Molecular weight: 101.1924
   • CAS number: 121-44-8, Density: 0.728 g/cm³ (20°C) 27
   • Boiling point: 89.5-90.5°C, Melting point: -115°C, Flash point: -6.7°C (Explosion limit 1.2%-8.0%) 24

2. Chemical Properties

   • Aqueous solution is alkaline (pH 12.7), slightly soluble in water (133 g/L, 20°C), easily soluble in ethanol
   • Stability: Flammable and explosive, requires light-protected and sealed storage (storage temperature ≤37°C) 47

II. Core Application Areas

1. Organic Synthesis

   • As a base catalyst: Used in Swern oxidation, Heck reaction, and preparation of silyl enol ethers 7
   • Solvent function: Participates in reactions such as ester/amide formation from acyl chlorides and dehydrohalogenation elimination reactions 67

2. Industrial Uses

   • Pharmaceuticals/Pesticides: Synthesis of drugs such as ampicillin and ketoconazole (consumption 0.5-8 tons per ton of product) 5
   • Polymer Materials: Polyurethane foaming catalyst (used in combination with TEDA), neutralizing agent for anionic waterborne polyurethane 7
   • Specialty Chemicals: Rubber vulcanization accelerator, tetrafluoroethylene polymerization inhibitor, component of rocket propellants 56

3. Analytical Detection

   • pH adjuster for HPLC mobile phase to improve peak shape of alkaline compounds