CX Fully Automated Chromatography Separation Unit

CX Fully Automated Chromatography System Composition and Features
◆ Automated Control System
The chromatography workstation, developed based on an advanced DCS distributed control strategy, enables control and data acquisition of pumps, valves, and various online detectors. It facilitates multi-column series and parallel operations, ensuring process stability and accuracy.
◆ Specialized Online Detection System for Traditional Chinese Medicine
Includes detection of conventional process parameters such as flow rate, pressure, temperature, pH (optional), and conductivity (optional), as well as real-time monitoring of active parts (or components) in traditional Chinese medicine using ultraviolet spectroscopy (optional) and near-infrared spectroscopy (optional).
◆ Chromatography Column Structure
The chromatography column features an excellent structural design with a reasonable height-to-diameter ratio, precise inlet and outlet fluid distribution devices, and is equipped with an automatic packing system and compressed air interface. This ensures effective column packing and filler regeneration, providing a foundation for high-efficiency separation.

Application of Chromatographic Separation Technology in the Separation and Purification of Natural Products:
In the separation and purification of traditional Chinese medicine, commonly used chromatographic techniques include adsorption chromatography and ion-exchange chromatography. Adsorption chromatography encompasses reverse-phase chromatography (C18 reverse-phase filler) and normal-phase silica gel chromatography. Ion-exchange chromatography is primarily used for the separation and purification of charged compounds. Currently, chromatographic separation technology plays an increasingly important role in refining active ingredients of traditional Chinese medicine, such as flavonoids, alkaloids, glycosides, organic acids, and polysaccharides.
During percolation, the solvent penetrates the cells of the medicinal material, dissolving a large amount of soluble substances. As the concentration increases and the density rises, the solvent moves downward. The upper extraction solvent or dilute extract replaces its position, creating a favorable concentration gradient that allows diffusion to occur naturally. Thus, percolation offers better extraction efficiency than maceration, achieves more complete extraction, and saves time by eliminating the need for separating the extract.

Control Interface
This system is specifically designed and developed for industrial-scale target compound purification in the pharmaceutical industry. The preparative liquid chromatography column has extremely high sample loading capacity, providing reliable assurance for increasing the preparation volume of purified products at a lower cost.