Methyl acetoacetate

Methyl acetoacetate (C₅H₈O₃) is a versatile organic compound primarily used in pesticides, pharmaceuticals, industrial solvents, and fine chemicals. Specific applications include:

I. Pesticide Synthesis Intermediate

1. Fungicides: Used in synthesizing hymexazol, dimethirimol, and ethirimol.
2. Insecticides: Serves as a key raw material for diazinon, coumaphos, and pirimiphos-methyl.
3. Herbicides and Rodenticides: Involved in producing imazethapyr (herbicide), coumatetralyl, and warfarin.

II. Pharmaceutical and Vitamin Manufacturing

1. Drug Synthesis: Used in antibiotic and vitamin B6 production.
2. Anti-HIV Drug Intermediate: Its derivative (methyl 4-methoxyacetoacetate) is a key component of the HIV drug dolutegravir.
3. Pharmaceutical Excipients: Functions as a solvent and organic synthesis carrier in some medicinal applications.

III. Industrial Solvents and Additives

1. Polymer Material Processing:
   • Acts as a co-solvent for cellulose ethers and resins, improving the flow properties of coatings and inks.
   • Used in PVC processing lubrication and polyurethane foam preparation.
2. Cleaning Agent Component: Dissolves grease and is applied in mechanical cleaning agents.

IV. Fine Chemical Raw Materials

1. Fragrance Synthesis: With natural fruity notes (e.g., pear, rose), it is used in food and daily chemical flavors.
2. Dyes and Polymer Stabilizers: Participates in dye synthesis and polymer performance modification.
3. Organic Synthesis Reagent: Commonly used in Claisen condensation, Michael addition, and other reactions.

️ V. Physical Properties and Safety Notes

Industry Status: In 2024, China added 5,000 tons of new production capacity, with 70% of demand concentrated in the vitamin and pesticide sectors.