Introduction to the Quality Standards, Uses, and Application Methods of Pharmaceutical-Grade Allantoin as an Active Pharmaceutical Ingredient.

Introduction to the Quality Standards, Uses, and Application Methods of Pharmaceutical-Grade Allantoin Preparations and Raw Materials

The following is an introduction to the quality standards, uses, and application methods of allantoin as a raw material:

Quality Standards for Pharmaceutical-Grade Allantoin

- Appearance: Typically a white crystalline powder, odorless, and tasteless.

- Content: Allantoin content should generally be no less than 99.0%.

- Melting Point: The melting point ranges between 228-232°C.

- Acidity and Alkalinity: pH value is generally between 5.5-7.0.

- Related Substances: Detected using methods such as high-performance liquid chromatography to control impurity levels, ensuring they do not exceed specified limits.

- Loss on Drying: Typically requires drying at 105°C to constant weight, with weight loss not exceeding 0.5%.

- Residue on Ignition: Should not exceed 0.1%.

Introduction to the Quality Standards, Uses, and Application Methods of Pharmaceutical-Grade Allantoin Preparations and Raw Materials

Uses of Pharmaceutical-Grade Allantoin

- Promoting Skin Wound Healing: Allantoin can stimulate skin cell metabolism, accelerate wound healing, and has significant restorative effects on skin injuries such as burns, scalds, and ulcers.

- Moisturizing and Skincare: It has excellent moisturizing properties, increases skin hydration, softens and smoothens the skin, and reduces dryness and cracking. It is commonly used in skincare products such as lotions, creams, and hand creams.

- Treating Skin Inflammation: It provides auxiliary treatment for certain skin inflammations like eczema and psoriasis, alleviating symptoms such as itching and redness while reducing inflammatory reactions.

Application Methods of Pharmaceutical-Grade Allantoin

- Preparation of Topical Formulations: In dermatological topical preparations, allantoin is often combined with other drugs or excipients. For example, when preparing creams, allantoin is first dissolved in an appropriate solvent and then mixed uniformly with an oily base, emulsifiers, etc., to form a cream of a specific concentration. The typical concentration of allantoin in creams ranges from 0.5% to 2%.

- Direct Application: For mild skin dryness or cracking, allantoin-containing skincare products or ointments can be applied directly to the affected area, gently massaged until absorbed, and used 2-3 times daily.

- Precautions: Avoid contact with eyes and other mucous membranes during use. If allergic or irritant symptoms such as redness, itching, or pain occur at the application site, discontinue use immediately, rinse with water, and consult a doctor if necessary. Follow the advice of a healthcare professional or the instructions on the product label, and avoid excessive or prolonged use.

The specific quality standards of allantoin raw materials may vary slightly among different manufacturers. In practical applications, refer to the corresponding quality standards and instructions. When using allantoin-related products, especially for treating skin diseases, it is best to do so under the guidance of a doctor.