Introduction to Pharmaceutical Grade Carbomer ABC Type Gel Matrix and Pharmaceutical Grade Carbomer Thickener Products

Introduction to Pharmaceutical Grade Carbomer ABC Type Gel Matrix and Pharmaceutical Grade Carbomer Thickener Products

Pharmaceutical grade carbomer is widely used in the medical field due to its excellent gel-forming and thickening properties. Below is an introduction to related products of pharmaceutical grade carbomer as a gel matrix and thickener:

- Pharmaceutical Grade Carbomer Gel Matrix

- Properties: Carbomer is a copolymer of polyalkyl sucrose or polyalkyl cross-linked with acrylic acid polymers, appearing as a white, loose powder with strong hygroscopicity and acidity due to the presence of a large number of acid groups. After neutralization with alkaline substances, the molecular chains disperse and extend, forming a gel.

- Mechanism of Action: After the carboxyl groups in the carbomer molecule are neutralized, negative charges are generated. Due to charge repulsion, the molecular chains expand and stretch, forming a three-dimensional network structure that encapsulates the liquid, resulting in a gel matrix.

- Common Types and Applications: Carbomer 940 is often used in topical preparations requiring high transparency, such as ophthalmic gels and oral mucosal gels. Carbomer 934 can be used as a base for external gel preparations, such as anti-inflammatory and analgesic gels, and skin gel patches, enabling sustained drug release and improved skin retention.

- Pharmaceutical Grade Carbomer Thickener

- Thickening Principle: Carbomer is weakly acidic in water. After neutralization with a neutralizing agent, negative charges are generated along the main chain, causing the molecular volume to expand and the diameter to increase, forming an extended structure that increases the viscosity of the system, achieving a thickening effect.

- Advantages: Carbomer provides efficient thickening at very low usage levels (typically 0.25-0.5%), allowing the preparation of products with a wide range of viscosities, from high viscosity with short rheology to low viscosity with long rheology. This is a capability unmatched by other thickeners such as CMC or natural gums.

- Common Types and Applications: Carbomer 941 has low viscosity and can produce stable emulsions or suspensions even in ionic solutions under various conditions. It is commonly used in transdermal topical preparations and low-viscosity gels with high transparency, as well as an emulsifying stabilizer in daily detergents and cosmetics. Carbomer 1342 offers high-efficiency thickening, producing clear and transparent water or alcohol-water colloids, and can serve as a rheology modifier in the presence of electrolytes.

Introduction to Pharmaceutical Grade Carbomer ABC Type Gel Matrix and Pharmaceutical Grade Carbomer Thickener Products

Pharmaceutical Grade Carbomer Gel Matrix: After neutralization, carbomer serves as an excellent gel matrix widely used in emulsions, creams, and gels.

Pharmaceutical Grade Carbomer Thickener: Carbomer can act as a thickener in pharmaceuticals to increase the viscosity of drug preparations, commonly used in liquid and semi-solid formulations.

Pharmaceutical Grade Carbomer Properties: Carbomer is a white, loose powder with strong hygroscopicity and certain acidic properties, which determine its application scope and usage methods.

Pharmaceutical Grade Carbomer 940: A common type of carbomer with short rheology and high viscosity, often used in topical preparations requiring high transparency, such as ophthalmic gels and oral mucosal gels.

Pharmaceutical Grade Carbomer 941: This type features long rheology and low viscosity, suitable for gels and emulsions, and can serve as a thickener for creams and lotions.