Pharmaceutical Grade Potassium Citrate White Crystalline Powder, Medical Grade Potassium Citrate, 500g per Bottle, National Drug Standard Code, Bulk API.

Pharmaceutical Grade Potassium Citrate White Crystal Powder Medical Grade Potassium Citrate 500g per Bottle National Medicine Permit Number Active Pharmaceutical Ingredient

As a commonly used clinical medication, pharmaceutical grade potassium citrate demonstrates significant efficacy in the treatment and prevention of various diseases. Its mechanism of action involves multiple physiological processes, which are detailed below.

1. Supplementing Potassium Ions and Correcting Hypokalemia

Potassium ions are important cations within human cells, playing a key role in maintaining normal cellular metabolism, neuromuscular excitability, and normal function. When the body loses excessive potassium due to various reasons (such as inadequate intake, vomiting, diarrhea, long-term use of potassium-wasting diuretics) or insufficient potassium intake, hypokalemia occurs. Hypokalemia can cause a range of symptoms, including muscle weakness and arrhythmias.

After ingestion, pharmaceutical grade potassium citrate dissociates into potassium ions in the gastrointestinal tract. These potassium ions enter the bloodstream through active transport and passive diffusion across the intestinal mucosal cells. They are then transported into the cells, replenishing the deficient intracellular potassium, restoring the balance of potassium concentrations inside and outside the cells, thereby correcting hypokalemia and restoring normal neuromuscular excitability and normal rhythm.

2. Regulating Acid-Base Balance and Improving Renal Tubular Acidosis

Renal tubular acidosis results from impaired renal tubule function, reducing the kidney's ability to regulate acid-base balance, leading to accumulation of acidic substances or loss of alkaline substances in the body, resulting in acidosis. In patients with type I distal renal tubular acidosis accompanied by hypokalemia, pharmaceutical grade potassium citrate plays a significant therapeutic role.

After metabolism in the body, the citrate ions from potassium citrate participate in the tricarboxylic acid cycle, ultimately being oxidized to carbon dioxide and water, and generating bicarbonate ions (HCO₃⁻). HCO₃⁻ is an important alkaline substance in the body that can neutralize excess acids, increase blood pH, and correct acidosis. Simultaneously, potassium supplementation helps improve the function of renal tubular cells, further promoting the restoration of acid-base balance.

3. Altering Urine Composition and Preventing Urinary System Stones

The formation of urinary system stones is closely related to the concentration and solubility of various components in urine. Pharmaceutical grade potassium citrate prevents urinary stones primarily through the following mechanisms:

Inhibiting Calcium Oxalate Stone Formation: In urine, calcium oxalate is one of the main components of kidney stones. The citrate ions from potassium citrate can bind with calcium ions to form soluble calcium citrate complexes. This reduces the concentration of free calcium ions in urine, decreasing the chance of calcium ions combining with oxalate ions to form calcium oxalate crystals, thereby inhibiting stone formation. Additionally, calcium citrate complexes have high solubility and are less likely to precipitate, helping prevent stone growth.

Dissolving Uric Acid Stones: Uric acid has low solubility in acidic urine and is prone to crystallize into stones. After ingestion, pharmaceutical grade potassium citrate increases urine pH, making it alkaline. In an alkaline environment, the solubility of uric acid significantly increases, and existing uric acid stones gradually dissolve, thus preventing and treating uric acid stones.

4. Influencing Electrophysiology and Alleviating Arrhythmias

In cases of arrhythmias caused by digitalis toxicity, pharmaceutical grade potassium citrate can also provide therapeutic benefits. Potassium ions significantly influence the electrophysiological properties of myocardial cells. During hypokalemia, myocardial cell excitability increases, automaticity enhances, and arrhythmias are more likely to occur. After supplementation with pharmaceutical grade potassium citrate, potassium ions enter myocardial cells, restoring the resting membrane potential, reducing excitability and automaticity, and improving conduction, thereby correcting arrhythmias caused by hypokalemia or digitalis toxicity and restoring normal rhythm.

Pharmaceutical Grade Potassium Citrate White Crystal Powder Medical Grade Potassium Citrate 500g per Bottle National Medicine Permit Number Active Pharmaceutical Ingredient

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