Integrin associated protein, IAP

CD47, also known as integrin associated protein (IAP), or OA3, is an important member of the immunoglobulin (Ig) superfamily and is widely expressed in different tissues and cells. CD47, also known as integrin associated protein (IAP), or OA3, is an important member of the immunoglobulin (Ig) superfamily and is widely expressed in different tissues and cells. The chemical characteristic of CD47 is a 40 to 60 kD membrane glycoprotein consisting of a 123aa extracellular domain, 5 highly hydrophobic extended transmembrane fragments, and 1 34aa short selectively spliced carboxyl end cytoplasmic tail region. The multiple regulatory roles of CD47 molecules in the body are mainly based on their interactions with signaling regulatory proteins, platelet reactive proteins, and integrins, participating in the regulation of transmembrane migration and phagocytosis of immune cells such as neutrophils, monocytes, and T cells; Promote the chemotaxis and diffusion of platelets, tumor cells, and smooth muscle cells; Inhibiting the release of IL-12 in monocytes while inhibiting the promotion of Th1 cell evolution by exogenous IL-12; In addition, it can also induce physiological processes such as lymphocyte apoptosis. CD47, as an important immune factor, plays a crucial role in the body's immune regulation.