Trichloroacetic acid

Main Applications

The applications of trichloroacetic acid are closely related to its strong acidity, corrosiveness, and its ability to precipitate organic matter:

Chemical Analysis and Laboratory

As a protein precipitant: In biochemistry, trichloroacetic acid can denature and precipitate proteins (the principle is to disrupt the hydrogen bonds and hydrophobic interactions of proteins), and is often used for the separation and purification of proteins or the removal of protein impurities from samples.

As a strong acid catalyst: Because its acidity is stronger than sulfuric acid, it can be used as a catalyst for certain organic synthesis reactions (such as esterification and condensation), and is particularly suitable for water-sensitive systems.

Medicine and Dermatology

Topical caustic agent: Low concentration (10%~30%) solutions can be used to treat skin hyperplastic diseases such as warts, corns, and seborrheic keratosis by corroding the diseased tissue to cause necrosis and shedding; high concentrations (50%~100%) can be used to cauterize the wart body or the root of the wart to remove necrotic tissue.

Chemical peeling agent: In medical cosmetology, diluted trichloroacetic acid solution can be used for chemical peeling to remove aging cuticles on the skin surface and improve problems such as pigmentation and wrinkles (concentration must be strictly controlled to avoid excessive skin damage).

Industrial Field

Organic synthesis intermediate: Used in the preparation of trichloroacetate esters, dyes, pesticides, etc. For example, derivatives of trichloroacetic acid can serve as raw materials for herbicides or insecticides.

Metal surface treatment: Utilizing its strong acidity and corrosiveness, it can be used for cleaning, derusting, or etching metal surfaces; however, due to its excessive corrosiveness, its scope of application is relatively narrow.

Environmental Protection Field

Used in wastewater treatment: It can adjust the pH value of wastewater, or be used in conjunction with other reagents to remove heavy metal ions from wastewater (through precipitation or complexation).

CAS NO: 76-03-9

EC NO: 200-927-2

Molecular Formula: C₂HO₂Cl₃

Molecular Weight: 162.3797

Alias: ;TCA;

Structural Formula: