N-Ethyl-p-Toluenesulfonamide

Packing:25kg or 50kg or ton bag into pallets.

Specification:  CAS NO.:8047-99-2;1321-54-6;80-39-7;

Appearance:white crystal powder Assay： 99.00 min. by HPLC IR Identity: conform to standard HNMR： conform to standard carbon spectrum: conform to standard Water by K. F.:0.5% max or as per the customer’s request Loss on drying:0.5% max. or as per the customer’s request

Used mainly in

Excellent plasticizer for polyamide resin and cellulose resin, with high compatibility.

Used in hot melt adhesives, coatings, and printing inks to improve flexibility and processing performance.

As a pharmaceutical intermediate, it is used for synthesizing active pharmaceutical ingredients.

It has applications in nylon, pigments, adhesives, and other fields.

Synthesis lines:

N-ethylortho/p-toluenesulfonylamide (CAS 8047-99-2) is typically synthesized using the following method:

Starting materials: o-toluenesulfonyl chloride or p-toluenesulfonyl chloride (or mixtures thereof).

Reaction type: Nucleophilic substitution reaction between sulfonyl chloride and ethylamine.

Reaction conditions:

Conducted in alkaline environments (such as triethylamine, sodium carbonate aqueous solution);

The solvent can be dichloromethane, acetonitrile, or a two-phase system of water/organic solvent;

The temperature is usually controlled between 0-40 ° C to avoid side reactions.

Product separation: Purification through extraction, washing, concentration, recrystallization, or 

vacuum distillation.

Product composition: The actual product is mostly a mixture of ortho - and para isomers (typical ratio: ortho 65-70%, para 25-30%).

This synthetic route belongs to a typical sulfonamide reaction and is widely used in the preparation of sulfonamide compounds