Pivalic acid

Packing:50kg,200kg,250kg drum

Specification:  CAS NO.:75-98-9

 Appearance: White needle-like crystals or white crystalline Assay: 99%min by HPLC IR Identity: conform to standard HNMR： conform to standard carbon spectrum: conform to standard Water by K. F.:0.5% max or as per the customer’s request Loss on drying:0.5% max. or as per the customer’s request

Used mainly in

Pharmaceutical intermediates: used for the synthesis of drugs such as ampicillin, cefazolin, fluorometholone, and bispecific adrenal glands.

Pesticide intermediates:

Aminomethyl ester insecticides (such as imidacloprid)

Herbicides (such as glyphosate)

Polymer materials:

Raw materials for olefin polymerization initiator TBPP (tert butyl peroxide)

Polyvinyl chloride (PVC) and paint stabilizer

Spices and daily chemicals: used for high-end spices, lubricants, adhesives, photosensitive materials, etc.

Organic synthesis: as an acid catalyst participating in reactions such as Claisen rearrangement; Its derivatives can be used to introduce tert butyl functional groups.

Synthesis lines:

According to authoritative public information, the main industrial synthesis methods include:

Reaction of isobutanol and formic acid catalyzed by concentrated sulfuric acid

Reaction equation:

(CH3)2CHCH2OH+HCOOH→H2SO4(CH3)3CCOOH(CH3)2CHCH2OH+HCOOHH2SO4(CH3)3CCOOH

The yield is about 76.8%.

Isobutene undergoes carbonylation reaction with carbon monoxide and water under the action of catalyst

This is a commonly used method in industry, with mild conditions and high atomic economy.

Reaction of tert butanol with formic acid in the presence of concentrated sulfuric acid

Similar to the isobutanol route, suitable for tertiary alcohol substrate 16.

Tert butyl chloride is converted into trimethylacetonitrile via sodium cyanide, and then subjected to acidic hydrolysis

Reaction equation:

(CH3)3CCl+NaCN→(CH3)3CCN→H+/H2O(CH3)3CCOOH(CH3)3CCl+NaCN→(CH3)3CCNH+/H2O(CH3)3CCOOH

Suitable for small-scale preparation of 610 in the laboratory.

High pressure carbonylation method (industrial grade):

Add the mixture of isobutene and trichloromethane into the high-pressure reactor

Add carbon monoxide at 5 MPa and room temperature, and react for 0.5 hours

After post-processing, 97% purity product was obtained with a yield of 74%