Trimethylacetyl chloride

Packing:50kg,200kg,250kg drum

Specification:  CAS NO.:3282-30-2

Used mainly in

used for synthesizing various antibiotics and drugs, including:

Amoxicillin (Amoxicillin)

Pesticide intermediates: used in the production of:

Carbamate insecticides (such as imidacloprid)

herbicides (such as isoxazolone and chlorfenapyr)

Plant protection products such as insecticides and herbicides

thirty-eight

•Other uses:

 Synthesis of peroxyesters (such as tert butyl peroxybutyrate)

Monomers or modifiers in polymer polymerization

Preparation of photosensitive materials and initiators (such as TBPP)

Synthesis lines:

According to authoritative sources, the mainstream synthesis methods for trimethylacetyl chloride are as follows:

1. Trimethylacetic acid chlorination method (most commonly used)

Raw material: trimethylacetic acid

Chlorination agent: Thionyl chloride (SOCl ₂)

Catalyst: Caprolactam (small amount)

Reaction conditions: Heat to 70 ℃, first remove sulfoxide chloride by vacuum distillation, and then collect the 105 ℃fraction by atmospheric distillation

Yield: Approximately 98%

Reaction formula: (CH3) 3CCOOH+SOCl2 →(CH3) 3CCOCl+SO2+HCl (CH3) 3CCOOH+SOCl2 →(CH3) 3CCOCl+SO2+HCl

2. Other methods (less commonly used):

Reaction of trimethylacetic acid with phosphorus trichloride (PCl ∝)

Carbonylation of tert butyl chloride and carbon monoxide in the presence of a catalyst

Isobutanol reacts with formic acid to produce trimethylacetic acid, which is then chlorinated