$Negotiation
Product Description: Packing:50kg,200kg,250kg drum
Specification: CAS NO.:3282-30-2
Used mainly in
used for synthesizing various antibiotics and drugs, including:
Amoxicillin (Amoxicillin)
Pesticide intermediates: used in the production of:
Carbamate insecticides (such as imidacloprid)
herbicides (such as isoxazolone and chlorfenapyr)
Plant protection products such as insecticides and herbicides
thirty-eight
•Other uses:
Synthesis of peroxyesters (such as tert butyl peroxybutyrate)
Monomers or modifiers in polymer polymerization
Preparation of photosensitive materials and initiators (such as TBPP)
Synthesis lines:
According to authoritative sources, the mainstream synthesis methods for trimethylacetyl chloride are as follows:
1. Trimethylacetic acid chlorination method (most commonly used)
Raw material: trimethylacetic acid
Chlorination agent: Thionyl chloride (SOCl ₂)
Catalyst: Caprolactam (small amount)
Reaction conditions: Heat to 70 ℃, first remove sulfoxide chloride by vacuum distillation, and then collect the 105 ℃fraction by atmospheric distillation
Yield: Approximately 98%
Reaction formula: (CH3) 3CCOOH+SOCl2 →(CH3) 3CCOCl+SO2+HCl (CH3) 3CCOOH+SOCl2 →(CH3) 3CCOCl+SO2+HCl
2. Other methods (less commonly used):
Reaction of trimethylacetic acid with phosphorus trichloride (PCl ∝)
Carbonylation of tert butyl chloride and carbon monoxide in the presence of a catalyst
Isobutanol reacts with formic acid to produce trimethylacetic acid, which is then chlorinated
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